https://www.celldesigninstitute.org/home daily 1.0 2023-05-16 https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1612419529951-C5BMOM20G9CBJKH95KPU/IMG_8679.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1611883299091-JQ2A0JNXXYAEUMO0G4U0/celldesign_infographic_4a.jpg Home - Click to see cell engineering infographic https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1612419565754-R2GDVLENYU80MJ35KH1B/iGEM_kids.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1611774315043-9A26H2N89IN6AQ40BZF9/Biden_UCSF_20160227_Biden_115+copy.jpg Home President & Dr. Biden discuss engineering cell therapies for cancer with CDI Director Wendell Lim. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1611884280194-89QZBGAXVBWEX7AFJSZ5/Lim_052_cropped%2Bcopy.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1606275728352-91OKU9VHWHYUL7X8S9XC/KTBYTydN_400x400.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1611884301414-VQUSRN9JWN4XEHHWWPFC/ElSamadHana2019.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689202169-JGW16OJ76FFHLY217ED4/iotn.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689280315-9CSF9JOZC9EOBQNVPVSF/UCSF_WIN_Logo_Navy_RGB_2K_FPO-pm.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1621268889337-JIKLQR3Q5D4XMERD39XH/Parker_Institute_for_Cancer_Immunotherapy_Logo.jpeg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689336077-DD4C2GRY06D7G43Y7DZH/ucsf_braintumor.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689405182-LKF15FQPYWJQSLN93O05/Screen+Shot+2021-03-23+at+12.03.41+PM.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689230469-T7G9X84XL2CS8DKFQV4I/ucsf-helen-diller-family-comprehensive-cancer-center-logo-vector.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689761379-CTCODGZQ6C5YFCEG9VX4/lewis+sigler.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689170068-BS2R43IGNIBUEPE8YGG8/moonshot.png Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616689146568-1YK7EH7OP8UO3TSGHNZO/1600px-DARPA_Logo.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/f93d9c80-62a1-45bb-9263-b7bcd27bce29/Hideho+Okada.jpeg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/ce276547-0deb-4fd8-9ab2-d80004fe0d9d/mignonlohwithpatient.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/130ad80d-339d-4bef-b485-71ec2a6c9a42/OphirKlein_sidebyside.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/70fd4390-c63a-4600-9018-1a897d3e0fb6/Stephen-Hauser-patient.jpg Home Steve Hauser - Neurology, Weil Institute https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/326b9722-8837-44ee-a358-953e7f771422/desai_tejal-40-copy.jpg Home Tejal Desai, Bioengineering https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/655aca15-adad-4c97-a09a-bffb7453300f/felix_feng-206opt.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/327ef06e-f4d6-488a-a8d0-1f28efac97d6/Zev-Gartner2.jpg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/3fc39ef0-d4fa-4b1b-bd5c-462719ae13d7/Andrew+Ko.jpeg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/19151718-daa8-4e94-a7e3-7ead93eb84a2/Michael+Wilson.jpeg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/353c2093-02e2-46b1-aed3-a59d9dab72f6/Alan+Ashworth.jpeg Home https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/0d36aa56-1ae8-4adf-a3a8-ad7745058e50/Dean+Sheppard.jpeg Home https://www.celldesigninstitute.org/publications daily 0.75 2022-12-16 https://www.celldesigninstitute.org/opportunities daily 0.75 2025-05-16 https://www.celldesigninstitute.org/tools daily 0.75 2021-03-16 https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1612561773002-6EYRAZJ4C0ZG3FPZUZ8J/IMG_1740.jpg Tools https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1612561865627-QXVEJDZ9A4DQW67UT8UU/IMG_1744.jpg Tools https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1612561895616-22Q4P3VEW18MQNMW0SNI/IMG_1750.jpg Tools https://www.celldesigninstitute.org/research daily 0.75 2021-03-25 https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1616629178749-0474FEZBIM57PQD8J271/CDL_webimage.jpg Research - Immune cell engineering Immune cells are an excellent platform for cell engineering, because they can be removed, genetically modified and re-transplanted. They also have the ability to patrol the body and the potential to migrate to sites of diverse diseases. Many of our engineered systems are being prototyped in T cells for treatment of cancer, autoimmunity, and other diseases. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1615878414562-C5BYZ917QHYZ0ZMOVXKV/Screen+Shot+2021-03-15+at+11.52.39+PM.png Research - Foundational toolkit for programming cell function Cellular decisions are made by regulatory circuits built from molecular components. Inspired by the range of molecular components that have arisen through evolution, we are developing a foundational toolkit of modular parts and circuits optimized for engineering of any type of novel cell behavior. The toolkit includes novel receptors, transcriptional controllers, epigenetic switches, protein expression and decay systems, systems for cytokine production/sensing/consumption, and cell adhesion/trafficking regulators. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1615878384826-WZ3AWPVFF5PNYLVCAD40/Screen+Shot+2021-03-15+at+11.53.17+PM.png Research - Computationally-guided cell design Any mature engineering field should be amenable to computationally-guided forward design. We are developing computational approaches and platforms for precision cell design, including bioinformatic pipelines to identify target antigen combinations, and multiscale (molecular, cellular, tissue) computational platforms to predictively model complex engineered cell behavior. We area also building sophisticated analysis tools to systematically quantify performance specifications of design, for example metrics to quantify the ability of feedback structures to reject disturbances. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1614883081575-0TVFE82S4MH4EIRL5OKV/xBraintumor.jpg.resize.jpg.pagespeed.ic.AnPHJzshHy.jpg Research - Cell therapies for the brain Treating diseases of the brain is extremely difficult, and engineered cells that can target the brain and cross the blood brain barrier present a potential platform for development of therapies. Working with collaborators at the UCSF Weill Institute for Neuroscience, we are engineering circuits that can effectively target immune cells to the brain or brain subregions, to deliver therapeutic actions to potentially treat a range of diseases, including brain tumors/metastases, neuroinflammation, and degeneration. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1614882991138-W1Y6KBGDA3MCK388QH8R/self-org.png Research - Engineering multi-cellular systems Living cells rarely act alone. Instead, the cells in our bodies constantly communicate with each other and self-organize into tissues or networks capable of forming complex structures and carrying out complex functions. We are developing tools for engineering multi-cellular communication and interaction to use for designing new tissues or driving developmental and regenerative programs. https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1614884146405-NPQR788MCEHO4YVF96NA/mignonlohwithpatient.jpg Research - Translation to the clinic A major priority of the CDI is to bring the power of cell engineering to patients. Thus, we are translating our research on engineering cells to a range of diseases, including cancers, autoimmunity, fibrosis, diabetes and neuroinflammation. We are working with a broad range of clinical colleagues to move innovative cell therapies to clinical trials. https://www.celldesigninstitute.org/news daily 0.75 2022-12-16 https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1614824108949-VFXJ7Z3WLT0KBC4ODY3O/Untitled+2.png News https://images.squarespace-cdn.com/content/v1/5fbdb7963dfdd95b60c14315/1621269028250-0DDGFGAXTC6CFD4NAEX8/Choe_STM_cover_highres.jpg News - Cancer therapeutic research from the Lim and Roybal labs at CDI featured on the cover of Science Translational Medicine! https://www.celldesigninstitute.org/donate daily 0.75 2020-11-25 https://www.celldesigninstitute.org/home2 daily 0.75 2021-01-27